Acetone → HCID 53729464, Verbindung

Reaktionsgleichung

[OH-].[Na+].[CH3:3][O:4][C:5]1[N:10]=[C:9]([O:11][CH3:12])[C:8]([CH:13]=O)=[C:7]([O:15][CH3:16])[N:6]=1.[CH3:17][C:18]([CH3:20])=[O:19]>O>[CH3:3][O:4][C:5]1[N:10]=[C:9]([O:11][CH3:12])[C:8]([CH:13]=[CH:17][C:18](=[O:19])[CH3:20])=[C:7]([O:15][CH3:16])[N:6]=1

Komponenten

Versuchsvorschrift

An aqueous solution of 2% sodium hydroxide (15 ml) was added to a stirred suspension of 2,4,6-trimethoxypyrimidine-5-carboxaldehyde (8 g) in acetone (15 ml) and water (15 ml). The mixture was stirred and refluxed for 4 hours, a precipitate slowly forming during this period. The suspension was diluted with water (100 ml) and extracted with chloroform (2×100 ml). The organic layer was washed with water, dried over magnesium sulphate and the solvent was removed by evaporation under reduced pressure to give 1-(2,4,6-trimethoxy-5-pyrimidyl)but-1-en-3-one as a pale yellow solid (8.0 g), mp 98°-99° C.