Hydrochloric Acid → (4,6-Dimethylpyrimidin-2-yl)cyanamide

HRID 542678

Reaktionsgleichung

Reaktionsgleichung von HRID 542678
[C:1]([NH:3][C:4]([NH2:6])=[NH:5])#[N:2].[CH3:7][C:8](=O)[CH2:9][C:10](=O)[CH3:11].Cl>O>[C:1]([NH:3][C:4]1[N:6]=[C:10]([CH3:11])[CH:9]=[C:8]([CH3:7])[N:5]=1)#[N:2]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 31261AcetylacetoneHCID 178418324HCID 178418324, Verbindung

Produkt 1

HCID 521618(4,6-Dimethylpyrimidin-2-yl)cyanamideAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

A mixture of 42 g (0.5 mol) of cyanoguanidine ("dicyanodiamide") and 50 g (0.5 mol) of pentane-2,4-dione ("acetylacetone") is heated to 120° C. for 15 hours. Thereafter, after the reaction mixture has been cooled, 500 ml of water are added and the solution is acidified with hydrochloric acid at 0° C. to 10° C. The product obtained in crystalline form in this procedure is isolated by being filtered off under suction. 51.8 g (70% of theory) of 2-cyanoamino-4,6-dimethyl-pyrimidine of melting point 205° C. are obtained.

Aufarbeitung

  1. temperatureThereafter, after the reaction mixture has been cooled
  2. customThe product obtained in crystalline form in this procedure
  3. customis isolated
  4. filtrationby being filtered off under suction

Quellen und Nachweise

ORD-Eintrag
ord-f14adb14524b4b93912b188aaac680b6
Quelldatensatz
uspto-grants-1987_04
Patentnummer
US04659364

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