Acetic Anhydride → N-(4-fluoro-2-(trifluoromethyl)phenyl)acetamide

HRID 54363

Reaktionsgleichung

Reaktionsgleichung von HRID 54363
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]([F:12])([F:11])[F:10].[C:13](OC(=O)C)(=[O:15])[CH3:14]>>[C:13]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]([F:12])([F:10])[F:11])(=[O:15])[CH3:14]

Komponenten

3

Edukt 2

HCID 7918Acetic AnhydrideHCID 678534-Fluoro-2-(trifluoromethyl)aniline

Produkt 1

HCID 10560920N-(4-fluoro-2-(trifluoromethyl)phenyl)acetamideAusbeute 98 %

Versuchsvorschrift

A solution of 2-amino-5-fluorobenzotrifluoride (2.025 g, 11.31 mmol, Aldrich) in acetic anhydride (10 mL) was stirred at room temperature for 12 h, and then most of the acetic anhydride was removed. The white needle crystals were collected by filtration, affording 2.445 g (98%) of 2-acetamido-5-fluorobenzotrifluoride. 1H NMR (CDCl3): δ2.205 (s, 3H); 7.229-7.335 (m, 3H); 8.055 (dd, 1H, J1 =4.8 Hz, J2 =8.4 Hz).

Aufarbeitung

  1. custommost of the acetic anhydride was removed
  2. filtrationThe white needle crystals were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-a0504cc7881b4d32806eb74fca5a23b5
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05622952

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