Formic Acid → HCID 15580711, Verbindung

HRID 543806Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 543806
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][CH2:11][C:10]([NH:13][C:14](=[O:19])C(F)(F)F)=[N:9]2)[CH:5]=[CH:6][CH:7]=1.C(O)=O.ClC1C=C(N2CC(C)C(NC=O)=N2)C=CC=1Cl>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][CH2:11][C:10]([NH:13][CH:14]=[O:19])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 284Formic AcidHCID 15580693HCID 15580693, VerbindungHCID 15580721HCID 15580721, Verbindung

Produkt 1

HCID 15580711HCID 15580711, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A mixture of 2.0 g. of 3-amino-1-(m-chlorophenyl)-2-pyrazoline (prepared in Example 10) and 10 ml. of a mixture of formic acid and acetic anhydride (Example 15) is allowed to stand at room temperature for 30 minutes. Then the solvent is evaporated in vacuo to give an oil. The oil is dissolved in dichloromethane and is columnized and recrystallized as described in Example 5 to give 1.32 g. of the desired product as pale yellow needles, m.p. 143°-145° C.

Aufarbeitung

  1. additionA mixture of 2.0 g
  2. customThen the solvent is evaporated in vacuo
  3. customto give an oil
  4. customrecrystallized
  5. customto give 1.32 g

Quellen und Nachweise

ORD-Eintrag
ord-5dd5727a5f334c8191869b11aeee9fef
Quelldatensatz
uspto-grants-1984_05
Patentnummer
US04447442

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