Quipazine → N-Ethyl-4-(quinolin-2-yl)piperazine-1-carbothioamide

HRID 544488Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 544488
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[N:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.[CH2:17]([N:19]=[C:20]=[S:21])[CH3:18]>CCOCC>[CH2:17]([NH:19][C:20]([N:14]1[CH2:15][CH2:16][N:11]([C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=2)[CH2:12][CH2:13]1)=[S:21])[CH3:18]

Komponenten

4

Edukt 2

HCID 5011QuipazineHCID 10966Ethyl isothiocyanate

Produkt 1

HCID 13318697N-Ethyl-4-(quinolin-2-yl)piperazine-1-carbothioamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a slurry of 4.26 g. of 1-(2-quinolinyl)piperazine in 30 ml. of anhydrousether is added dropwise a solution of 1.74 g. of ethyl isothiocyanate in 30ml. of anhydrous ether. The mixture is stirred for one hour and the resulting solid is collected and recrystallized from 150 ml. of ethanol, giving 4.43 g. of the desired product as a white crystalline solid, m.p. 193°-195° C.

Aufarbeitung

  1. additionof anhydrousether is added dropwise a solution of 1.74 g
  2. customthe resulting solid is collected
  3. customrecrystallized from 150 ml
  4. customof ethanol, giving 4.43 g

Quellen und Nachweise

ORD-Eintrag
ord-326458202523403b945fdb1e247f5272
Quelldatensatz
uspto-grants-1984_05
Patentnummer
US04450272

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