2-Fluorophenyl isothiocyanate → 2'-Fluoro-4-(2-pyrazinyl)-1-piperazinethiocarboxanilide

Beteiligte Stoffe

Reaktionsschritte

To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 50 ml. of anhydrous ether is added a solution of 4.59 g. of 2-fluorophenyl isothiocyanate in 50 ml. of anhydrous ether over a period of 10 minutes. The mixture is stirred for 30 minutes and the resulting solid is collectedand then recrystallized from 200 ml. of ethanol, giving 7.04 g. of the desired product, m.p. 151°-153° C.

Herkunft & Nachweise