2-Fluorophenyl isothiocyanate → 2'-Fluoro-4-(2-pyrazinyl)-1-piperazinethiocarboxanilide

HRID 544490Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 544490
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]=[C:21]=[S:22]>CCOCC>[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[NH:20][C:21]([N:10]1[CH2:9][CH2:8][N:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)[CH2:12][CH2:11]1)=[S:22]

Komponenten

4

Edukt 2

HCID 975202-Fluorophenyl isothiocyanateHCID 27346391-Piperazinylpyrazine

Produkt 1

HCID 133186942'-Fluoro-4-(2-pyrazinyl)-1-piperazinethiocarboxanilide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 50 ml. of anhydrous ether is added a solution of 4.59 g. of 2-fluorophenyl isothiocyanate in 50 ml. of anhydrous ether over a period of 10 minutes. The mixture is stirred for 30 minutes and the resulting solid is collectedand then recrystallized from 200 ml. of ethanol, giving 7.04 g. of the desired product, m.p. 151°-153° C.

Aufarbeitung

  1. customthen recrystallized from 200 ml
  2. customof ethanol, giving 7.04 g

Quellen und Nachweise

ORD-Eintrag
ord-b8ccbe605ef04daf82a06593a3331c0c
Quelldatensatz
uspto-grants-1984_05
Patentnummer
US04450272

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