2-Chloro-3-(trifluoromethyl)pyridine → 2-Methoxy-3-(trifluoromethyl)pyridine

HRID 545068

Reaktionsgleichung

Reaktionsgleichung von HRID 545068
Cl[C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:12][O-:13].[Na+]>CO>[CH3:12][O:13][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:5]=[CH:4][N:3]=1

Komponenten

4

Edukt 2

HCID 5898332-Chloro-3-(trifluoromethyl)pyridineHCID 10942334Sodium Methoxide

Produkt 1

HCID 27753092-Methoxy-3-(trifluoromethyl)pyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Heat a mixture of 2-chloro-3-trifluoromethyl-pyridine (1.8 g, 10 mmol) and sodium methoxide (4M, 5 mL, 20 mmol) in MeOH (20 mL) at reflux for 18 hours. Cool the mixture and remove the volatiles by rotary evaporation. Dissolve the residue in EtOAc (50 mL) and wash with water (50 mL), saturated NaHCO3(aq) (50 mL) and brine (50 mL). Dry the organic extract over MgSO4 and remove the solvent under reduced pressure to yield the title compound.

Aufarbeitung

  1. temperatureHeat
  2. temperatureat reflux for 18 hours
  3. temperatureCool the mixture
  4. customremove the volatiles
  5. customby rotary evaporation
  6. dissolutionDissolve the residue in EtOAc (50 mL)
  7. washwash with water (50 mL), saturated NaHCO3(aq) (50 mL) and brine (50 mL)
  8. customDry the
  9. extractionorganic extract over MgSO4
  10. customremove the solvent under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7dceeb3bdea34bc9b81ebf9dac1ee8d5
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07935702B2

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