Bromine → 1-(5-Bromo-3-(trifluoromethyl)pyridin-2-yl)ethanol
Reaktionsgleichung
[F:1][C:2]([F:13])([F:12])[C:3]1[C:4]([CH:9]([OH:11])[CH3:10])=[N:5][CH:6]=[CH:7][CH:8]=1.[Br:14]Br>CO>[Br:14][C:7]1[CH:8]=[C:3]([C:2]([F:1])([F:12])[F:13])[C:4]([CH:9]([OH:11])[CH3:10])=[N:5][CH:6]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Dissolve 1-(3-(trifluoromethyl)pyridin-2-yl)ethanol (8.8 g, 0.046 moles) in anhydrous MeOH (80 mL) and add bromine (2.35 mL) dropwise at room temperature. Reflux the mixture under N2 atmosphere for 3 weeks with the addition of bromine (1.0 mL) on each day. Concentrate the reaction mixture under vacuum, dilute with water (100 mL), neutralize with NaHCO3, extract with EtOAc (3×100 mL) and dry (MgSO4). Filter the dried extract and concentrate under vacuum to afford a yellow oil. Purify the crude product by column chromatography to afford the title compound as a pale yellow oil.