1,2-Epoxy-3-fluoropropane → 1-Fluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-ol

HRID 545238

Reaktionsgleichung

Reaktionsgleichung von HRID 545238
[CH2:1]([CH:3]1[O:5][CH2:4]1)[F:2].[N+:6]([C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[CH:11][CH:10]=1)([O-:8])=[O:7]>C(O)C>[F:2][CH2:1][CH:3]([OH:5])[CH2:4][N:18]1[CH2:19][CH2:20][N:15]([C:12]2[CH:11]=[CH:10][C:9]([N+:6]([O-:8])=[O:7])=[CH:14][CH:13]=2)[CH2:16][CH2:17]1

Komponenten

4

Edukt 2

HCID 104181,2-Epoxy-3-fluoropropaneHCID 804471-(4-Nitrophenyl)piperazine

Produkt 1

HCID 671710891-Fluoro-3-[4-(4-nitrophenyl)piperazin-1-yl]propan-2-olAusbeute 43,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Ethanol (15 mL) solution of 272 mg of epifluorohydrin and 500 mg of 1-(4-nitrophenyl)piperazine was heated under reflux for 15 hours, and then the reaction liquid was concentrated under reduced pressure. The residue was solidified from ethyl acetate to obtain 300 mg of the entitled compound as a yellow solid.

Aufarbeitung

  1. temperatureunder reflux for 15 hours
  2. customthe reaction liquid
  3. concentrationwas concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d7023ffab59d484ebf7ad48ae95afa9f
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07935708B2

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