Ammonium Chloride → 1-(6-Bromo-2-pyridinyl)ethanol

HRID 545250Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 545250
[BH4-].[Na+].[C:3]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([Br:12])[N:7]=1)(=[O:5])[CH3:4].[Cl-].[NH4+]>C(O)C>[Br:12][C:8]1[N:7]=[C:6]([CH:3]([OH:5])[CH3:4])[CH:11]=[CH:10][CH:9]=1

Komponenten

5

Edukt 3

HCID 25517Ammonium ChlorideHCID 4311764Sodium borohydrideHCID 112985782-Acetyl-6-bromopyridine

Produkt 1

HCID 110634791-(6-Bromo-2-pyridinyl)ethanolAusbeute 100,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

With cooling with ice, 426 mg of sodium borohydride was added to ethanol (50 mL) solution of 4.50 g of 2-acetyl-6-bromopyridine. After stirred for 1 hour, aqueous saturated ammonium chloride solution was added to the reaction liquid, extracted with ethyl acetate, washed with saturated saline water, and dried with anhydrous magnesium sulfate. After concentrated under reduced pressure, 4.58 g of the entitled compound was obtained as a colorless oily substance.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washwashed with saturated saline water
  3. dry with materialdried with anhydrous magnesium sulfate
  4. concentrationAfter concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0473f1e63db4488d879b1076ef22b2cb
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07935708B2

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