Sodium methanethiolate → 4-Methoxy-3-(methylthio)-6-[3-(trifluoromethyl)phenyl]pyridazine

HRID 54655Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 54655
Cl[C:2]1[N:3]=[N:4][C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)=[CH:6][C:7]=1[O:8][CH3:9].[CH3:20][S-:21].[Na+]>C1COCC1>[CH3:9][O:8][C:7]1[CH:6]=[C:5]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[N:4]=[N:3][C:2]=1[S:21][CH3:20]

Komponenten

4

Edukt 2

HCID 4378561Sodium methanethiolateHCID 199596893-Chloro-4-methoxy-6-[3-(trifluoromethyl)phenyl]pyridazine

Produkt 1

HCID 199596674-Methoxy-3-(methylthio)-6-[3-(trifluoromethyl)phenyl]pyridazineAusbeute 88,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

3-Chloro-4-methoxy-6-[3-(trifluoromethyl)phenyl]pyridazine (2.0 g, 0.0069 mole, Compound No. 48) and sodium thiomethoxide (0.5 g, 0.0069 mole) were refluxed overnight under N2 in THF (50 mL). After this time no starting material was present by TLC. The mixture was partitioned between EtOAc-water. The aqueous layer was extracted again with EtOAc. The EtOAc layers were combined, washed with brine, dried (MgSO4), filtered and evaporated to give a crude oil. The oil was chromatographed on a Prep-500 using EtOAc-cyclohexane (3:17) to give 4-methoxy-3-(methylthio)-6-[3-(trifluoromethyl)phenyl]pyridazine (1.83 g, 88% yield, Compound No. 64) as a white solid.

Aufarbeitung

  1. customThe mixture was partitioned between EtOAc-water
  2. extractionThe aqueous layer was extracted again with EtOAc
  3. washwashed with brine
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. customevaporated
  7. customto give a crude oil
  8. customThe oil was chromatographed on a Prep-500 using EtOAc-cyclohexane (3:17)

Quellen und Nachweise

ORD-Eintrag
ord-4892165b741043b8a4528e20cb38e091
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05623072

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