Acetic Acid → Methyl 2-(5-bromo-2-methoxyphenyl)acetate

HRID 547145

Reaktionsgleichung

Reaktionsgleichung von HRID 547145
C[Si](C=[N+]=[N-])(C)C.[Br:8][C:9]1[CH:10]=[CH:11][C:12]([O:19][CH3:20])=[C:13]([CH2:15][C:16]([OH:18])=[O:17])[CH:14]=1.[C:21](O)(=O)C>CO.C1(C)C=CC=CC=1>[CH3:21][O:17][C:16](=[O:18])[CH2:15][C:13]1[CH:14]=[C:9]([Br:8])[CH:10]=[CH:11][C:12]=1[O:19][CH3:20]

Komponenten

6

Edukt 3

HCID 176Acetic AcidHCID 167693TrimethylsilyldiazomethaneHCID 5553065-Bromo-2-methoxyphenylacetic acid

Produkt 1

HCID 21999895Methyl 2-(5-bromo-2-methoxyphenyl)acetateAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 1140TolueneLösungsmittel

Versuchsvorschrift

Trimethylsilyldiazomethane (2 M solution in diethyl ether, 0.306 mL, 0.612 mmol) was added to a solution of (5-bromo-2-methoxy-phenyl)-acetic acid (100 mg, 0408 mmol) in methanol (1 mL) and toluene (4 mL), and the mixture was stirred at room temperature for 30 minutes. Acetic acid was added to the reaction mixture to terminate the reaction, and then the mixture was concentrated under reduced pressure to give the target compound as a colorless oil (103.7 mg, 98%).

Aufarbeitung

  1. customto terminate
  2. customthe reaction
  3. concentrationthe mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-da01d3947f874f5b9db67375d3a68dac
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07935688B2

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