Water → 2-(3,5-Dichlorophenyl)-2-methylpropanoic acid

HRID 547751Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 547751
C[O:2][C:3](=[O:15])[C:4]([C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[C:9]([Cl:14])[CH:8]=1)([CH3:6])[CH3:5].O>C(O)C>[Cl:13][C:11]1[CH:12]=[C:7]([C:4]([CH3:6])([CH3:5])[C:3]([OH:15])=[O:2])[CH:8]=[C:9]([Cl:14])[CH:10]=1

Komponenten

4

Edukt 2

HCID 962WaterHCID 671939532-(3,5-Dichloro-phenyl)-2-methyl-propionic acid methyl ester

Produkt 1

HCID 589907192-(3,5-Dichlorophenyl)-2-methylpropanoic acidAusbeute 98,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 9.0 g (36 mmol) 2-(3,5-dichloro-phenyl)-2-methyl-propionic acid methyl ester in 40 ml ethanol 40 ml 2 N sodium hydroxide solution was added. After stirring for 4 hrs at RT 150 ml water was added and the solution washed twice with 200 ml Et2O. The aqueous phase was acidified with 25% hydrochloric acid solution and three times extracted with 150 ml CH2Cl2. The combined organic layers were dried (Na2SO4), filtered and evaporated to yield 8.3 g (97%) 2-(3,5-dichloro-phenyl)-2-methyl-propionic acid as a off-white solid.

Aufarbeitung

  1. additionwas added
  2. washthe solution washed twice with 200 ml Et2O
  3. extractionextracted with 150 ml CH2Cl2
  4. dry with materialThe combined organic layers were dried (Na2SO4)
  5. filtrationfiltered
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-ae7cf2c6725c40ed91ec22883b398bcc
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07939533B2

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