Hydrochloric Acid → 3-(2',4',5'-Trifluoro-biphenyl-4-yloxymethyl)-phenylamine hydrochloride

HRID 547860Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 547860
[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([N+:24]([O-])=O)[CH:19]=2)=[CH:12][CH:11]=1.[ClH:27]>CCOC(C)=O.CCO.[Pd]>[ClH:27].[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH2:17][C:18]2[CH:19]=[C:20]([NH2:24])[CH:21]=[CH:22][CH:23]=2)=[CH:12][CH:11]=1

Komponenten

6

Edukt 2

HCID 313Hydrochloric AcidHCID 58287797HCID 58287797, Verbindung

Produkt 1

HCID 671537603-(2',4',5'-Trifluoro-biphenyl-4-yloxymethyl)-phenylamine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A solution of 2,4,5-trifluoro-4′-(3-nitro-benzyloxy)-biphenyl (150 mg, 0.418 mmol) and 10% Pd/C (40 mg) in EtOAc (2 mL), EtOH (10 mL) and 6N HCl (100 uL) was hydrogenated at 50 psi for 1.25 hrs. The reaction mixture was filtered through Celite and evaporated to dryness to give 3-(2′,4′,5′-trifluoro-biphenyl-4-yloxymethyl)-phenylamine hydrochloride. LC-MS (ES) calculated for C19H14F3NO, 329.32; found m/z 330 [M+H]+.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite
  2. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-414057368e5240a7ace24cd2a40016bf
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07939569B1

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