Ethylene Glycol → 1,4-Dioxa-8-thiaspiro(4.5)decane

HRID 54831

Reaktionsgleichung

Reaktionsgleichung von HRID 54831
[S:1]1[CH2:6][CH2:5][C:4](=[O:7])[CH2:3][CH2:2]1.[CH2:8](O)[CH2:9][OH:10].C1(C)C=CC(S(O)(=O)=O)=CC=1.C1C=CC=CC=1>O>[O:10]1[C:4]2([CH2:5][CH2:6][S:1][CH2:2][CH2:3]2)[O:7][CH2:8][CH2:9]1

Komponenten

6

Edukt 4

HCID 174Ethylene GlycolHCID 241BenzeneHCID 6101p-Toluenesulfonic acidHCID 66173Tetrahydrothiopyran-4-one

Produkt 1

HCID 123359781,4-Dioxa-8-thiaspiro(4.5)decane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A mixture of 5.0 g of tetrahydrothiopyran-4-one, 2.5 ml of ethylene glycol, 0.230 g of p-toluenesulfonic acid and 125 ml of benzene is stirred at reflux temperature for 2.5 hours. The water formed is removed using a Dean-Stark trap. The reaction is treated with saturated sodium bicarbonate, water, saturated sodium chloride, dried and concentrated in vacuo to give 6.52 g of the desired product as an oil.

Aufarbeitung

  1. temperatureat reflux temperature for 2.5 hours
  2. customis removed
  3. additionThe reaction is treated with saturated sodium bicarbonate, water, saturated sodium chloride
  4. customdried
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3e940006c8d94ab8a3f705c659dcaa0b
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05623081

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