2-Phenylpyridine → 2-(2-Bromophenyl)pyridine

Temperatur

0 °C

3 g (19.3 mmol) of 2-phenylpyridine and 40 mg (0.716 mmol) of an iron powder were mixed and stirred. 4.0 g (25 mmol) of bromine was dropped paying attention to heat generation while stirring and cooling the mixture to 0° C., and the mixture was heated up to 90° C. and stirred for 10 hours. After completion of the reaction, this reaction mixture was dissolved in chloroform, and washed with a 5% aqueous sodium thiosulfate solution. The chloroform solution was dried over sodium sulfate, then, concentrated, and the residue was purified by silica gel column chromatography, to obtain the intended 2-(bromophenyl)pyridine.

1. temperatureto heat generation
2. stirringwhile stirring
3. temperaturethe mixture was heated up to 90° C.
4. stirringstirred for 10 hours
5. customAfter completion of the reaction
6. washwashed with a 5% aqueous sodium thiosulfate solution
7. dry with materialThe chloroform solution was dried over sodium sulfate
8. concentrationconcentrated
9. customthe residue was purified by silica gel column chromatography

ORD-Eintrag

ord-66625216ddc04b3990b0170475934285

Quelldatensatz

uspto-grants-2011_05

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07947340B2