Hydrazine → Methyl 3-amino-2,2-dimethylpropanoate

HRID 550595Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 550595
NN.O=C1C2C(=CC=CC=2)C(=O)[N:5]1[CH2:14][C:15]([CH3:21])([CH3:20])[C:16]([O:18][CH3:19])=[O:17]>CO.C(OCC)C>[NH2:5][CH2:14][C:15]([CH3:21])([CH3:20])[C:16]([O:18][CH3:19])=[O:17]

Komponenten

5

Edukt 2

HCID 9321HydrazineHCID 11173032methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2,2-dimethylpropanoate

Produkt 1

HCID 13285789Methyl 3-amino-2,2-dimethylpropanoateAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
65 °C

Versuchsvorschrift

Hydrazine (1.1 eq., 0.27 mL, 8.42 mmol) was added to the solution of methyl 3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2,2-dimethylpropanoate (0.2 g, 7.66 mmol) in methanol (60 mL) maintained under magnetic stirring at 65° C. After 5 hours the reaction mixture was allowed to cool to room temperature, diluted with diethyl ether and filtered. The filtrate was washed thoroughly with diethyl ether. The title compound was obtained after evaporation of the solvents and it was used in the next step without any further purification. (0.8 g, 75% yield).

Aufarbeitung

  1. temperaturemaintained
  2. temperatureto cool to room temperature
  3. filtrationfiltered
  4. washThe filtrate was washed thoroughly with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-32d89bb6a91c4421868a5048b955acc7
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07947686B2

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