Hydrochloric Acid → Lithium Chloride

HRID 55117Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 55117
C[O:2][C:3](=[O:19])[C@@H:4]1[CH2:8][CH2:7][C:6](=[O:9])[N:5]1[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]#[N:18])=[CH:13][CH:12]=1.[Li+:20].[OH-].[ClH:22]>C1COCC1.O>[C:17]([C:14]1[CH:13]=[CH:12][C:11]([CH2:10][N:5]2[C:6](=[O:9])[CH2:7][CH2:8][C@H:4]2[C:3]([OH:19])=[O:2])=[CH:16][CH:15]=1)#[N:18].[Li+:20].[Cl-:22]

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 54410854N-(4-Cyanobenzyl)-L-pyroglutamic acid methyl ester

Produkt 2

HCID 433294Lithium ChlorideHCID 22872280N-(4-Cyanobenzyl)-L-pyroglutamic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21881883Oxolane--water (1/1)Lösungsmittel

Versuchsvorschrift

N-(4-Cyanobenzyl)-L-pyroglutamic acid methyl ester (0.875 g, 0.0034 mol) was dissolved in THF:H2O (3:1) (12 mL) and treated with LiOH (0.294 g, 0.007 mol) with stirring at ambient temperature. After stirring for 3 h, the solution was neutralized with 1N HCl, and concentrated to dryness to give the title compound and 2.1 eq of LiCl which was used without further purification.

Aufarbeitung

  1. stirringAfter stirring for 3 h
  2. concentrationconcentrated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-f2485a4c07ac4dc0821a11680da6b71a
Quelldatensatz
uspto-grants-1997_04
Patentnummer
US05624936

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