Sodium Hydroxide → HCID 21914113, Verbindung

HRID 551407Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 551407
[CH:1]([CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]1[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=O.[C:19]([O-])(=O)[CH3:20].[NH4+:23].[OH-].[Na+]>C(O)(=O)C>[CH3:1][C:3]1[NH:4][C:1]([CH:3]2[CH2:11][C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[N:4]2[C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=[N:23][C:11]=1[CH2:10][CH2:19][CH3:20]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 517165Ammonium AcetateHCID 21914148HCID 21914148, Verbindung

Produkt 1

HCID 21914113HCID 21914113, VerbindungAusbeute 255,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Intermediate (12) (0.00101 mole), 2-3-hexanedione (0.004 mole), and ammonium acetate (0.025 mole) were combined in acetic acid (4 ml), and immediately placed on a steam bath for 15 minutes. After 2 hours at room temperature, the reaction was poured into ice water (100 ml), basified with 3N NaOH, and extracted with diethylether (twice). The organic phases were combined, dried, filtered, and concentrated. The residue was taken up in diethylether, concentrated and then purified by prep LC, yielding 0.440 g of 1,1-dimethylethyl 2,3-dihydro-2-(5-methyl-4-propyl-1H-imidazol-2-yl)-1H-indole-1-carboxylate (compound 99).

Aufarbeitung

  1. waitAfter 2 hours at room temperature
  2. extractionextracted with diethylether (twice)
  3. customdried
  4. filtrationfiltered
  5. concentrationconcentrated
  6. concentrationconcentrated
  7. custompurified by prep LC

Quellen und Nachweise

ORD-Eintrag
ord-5e436a2611b64396ade2eea34bd3e692
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07947713B2

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