Formamide → 7-Nitroquinazolin-4(3H)-one

HRID 552991

Reaktionsgleichung

Reaktionsgleichung von HRID 552991
[N+:1]([C:4]1[CH:5]=[C:6]([NH2:13])[C:7](=[CH:11][CH:12]=1)[C:8]([OH:10])=O)([O-:3])=[O:2].[CH:14]([NH2:16])=O>>[N+:1]([C:4]1[CH:5]=[C:6]2[C:7]([C:8](=[O:10])[NH:16][CH:14]=[N:13]2)=[CH:11][CH:12]=1)([O-:3])=[O:2]

Komponenten

3

Edukt 2

HCID 713FormamideHCID 120764-Nitroanthranilic acid

Produkt 1

HCID 862228007-Nitroquinazolin-4(3H)-oneAusbeute 95 %

Reaktionsbedingungen

Temperatur
165 °C

Versuchsvorschrift

A mixture of 4-nitroanthranilic acid (2.17 g, 11.91 mmol) and formamide (1.5 mL, 38.43 mmol) was heated at 165° C. for 4 hours. The warm reaction mixture was poured into ice/water (30 mL) and the resulting precipitate was collected via filtration, to give an orange solid (2.16 g, 95% yield) which was dried over P2O5. This was used without further purification.

Aufarbeitung

  1. customThe warm reaction mixture
  2. filtrationthe resulting precipitate was collected via filtration

Quellen und Nachweise

ORD-Eintrag
ord-6dcf723364054cfd9ee23aaa35eca442
Quelldatensatz
uspto-grants-2011_05
Patentnummer
US07951955B2

Verknüpfte Notizen

Wird geladen…