Water → 4-(3-(3-Carboxypropanoyl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-7-yl)benzoic acid

HRID 553540Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 553540
C([O:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:23]=[C:22]3[C:17]([C:18]([OH:33])=[C:19]([C:26](=[O:32])[CH2:27][CH2:28][C:29]([OH:31])=[O:30])[C:20](=[O:25])[N:21]3[CH3:24])=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)=[O:7])(C)(C)C.OC1C2C(=CC(C3C=CC(C(OC(C)(C)C)=O)=CC=3)=CC=2)N(C)C(=O)C=1C(=O)CCC=O.OOS([O-])=O.[K+].O>CN(C=O)C>[C:29]([CH2:28][CH2:27][C:26]([C:19]1[C:20](=[O:25])[N:21]([CH3:24])[C:22]2[C:17]([C:18]=1[OH:33])=[CH:16][CH:15]=[C:14]([C:11]1[CH:10]=[CH:9][C:8]([C:6]([OH:7])=[O:5])=[CH:13][CH:12]=1)[CH:23]=2)=[O:32])([OH:31])=[O:30]

Komponenten

6

Edukt 4

HCID 962WaterHCID 23707502Potassium hydroxy sulfiteHCID 67407862HCID 67407862, VerbindungHCID 86631268HCID 86631268, Verbindung

Produkt 1

HCID 547473424-(3-(3-Carboxypropanoyl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-7-yl)benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

4-(7-(4-(tert-Butoxycarbonyl)phenyl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)-4-oxobutanoic acid. tert-Butyl 4-(4-hydroxy-1-methyl-2-oxo-3-(4-oxobutanoyl)-1,2-dihydroquinolin-7-yl)benzoate (130 mg, 299 μmol) was dissolved in DMF (1493 μl). Oxone (184 mg, 299 μmol) was added to the mixture at room temperature, and the resulting mixture was stirred for 1 hour. Water was added to precipitate the product from solution. The mixture was filtered, washed with water and ether, and dried in a vacuum oven to give the title compound as an off-white solid.

Aufarbeitung

  1. customto precipitate the product from solution
  2. filtrationThe mixture was filtered
  3. washwashed with water and ether
  4. customdried in a vacuum oven

Quellen und Nachweise

ORD-Eintrag
ord-228cd640d6ac479e8b36b48feaac7fe1
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08048894B2

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