HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Phosphate, Tribasic → Methyl 6-methyl-2-phenylpyrimidine-4-carboxylate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Edukt | Phenylboronic Acid | HCID 66827 | — |
| Edukt | Methyl 2-chloro-6-methylpyrimidine-4-carboxylate | HCID 2736835 | — |
| Edukt | Water ethylacetate | HCID 22728543 | — |
| Katalysator | HCID 178418397 | HCID 178418397 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | Methyl 6-methyl-2-phenylpyrimidine-4-carboxylate | HCID 58101529 | — |
Reaktionsschritte
2-chloro-6-methyl-pyrimidine-4-carboxylic acid methyl ester (930 mg), phenylboronic acid (610 mg), tetrakis(triphenylphosphine)palladium (265 mg) and potassium phosphate (2.12 g) were dissolved in anhydrous dioxane (25 ml) under argon. The mixture was refluxed overnight and worked up with water/EA. The org. phases were dried (Na2SO4) and evaporated off. Column chromatography (EA/Hept 1/5) offered 875 mg of the desired compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08048881B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-99a308eb50b24b91a6980a55a346e494 |
| Quellennotiz | uspto-grants-2011_11 |