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HRID553826

反应详情

EQUATION

反应方程式

HRID 553826 的结构方程式

REACTANTS

反应物

4
结构：O=P([O-])([O-])[O-].[K+].[K+].[K+]
HCID62657

Tripotassium phosphate

K3O4P

结构：OB(O)c1ccccc1
HCID66827

Boronic acid, phenyl-

C6H7BO2

结构：COC(=O)c1cc(C)nc(Cl)n1
HCID2736835

Methyl 2-chloro-6-methylpyrimidine-4-carboxylate

C7H7ClN2O2

结构：CCOC(C)=O.O
HCID22728543

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1cc(C)nc(-c2ccccc2)n1
HCID58101529

Methyl 6-methyl-2-phenyl-4-pyrimidinecarboxylate

C13H12N2O2

AUXILIARIES

试剂、催化剂与溶剂

2
结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
催化剂HCID178418397

未命名化合物

结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

2-chloro-6-methyl-pyrimidine-4-carboxylic acid methyl ester (930 mg), phenylboronic acid (610 mg), tetrakis(triphenylphosphine)palladium (265 mg) and potassium phosphate (2.12 g) were dissolved in anhydrous dioxane (25 ml) under argon. The mixture was refluxed overnight and worked up with water/EA. The org. phases were dried (Na2SO4) and evaporated off. Column chromatography (EA/Hept 1/5) offered 875 mg of the desired compound.

WORKUP

后处理

  1. temperatureThe mixture was refluxed overnight
  2. dry with materialphases were dried (Na2SO4)
  3. customevaporated off