HCID 178424903, Verbindung → HCID 178465153, Verbindung

HRID 555227Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 555227
CC1C(C)=C(C(C2N=CNC=2)C)C=CC=1.[CH3:16][CH2:17][NH:18][C:19]([C@H:21]1[N:25]([C:26]([C@@H:28]([NH:36][C:37]([C@@H:39]([NH:44][C:45]([C@H:47]([NH:52][C:53]([C@@H:55]([NH:64][C:65]([C@@H:67]([NH:70][C:71]([C@@H:73]([NH:84][C:85]([C@@H:87]([NH:94][C:95]([C@H:97]2[NH:102][C:100](=[O:101])[CH2:99][CH2:98]2)=[O:96])[CH2:88][C:89]2[N:93]=[CH:92][NH:91][CH:90]=2)=[O:86])[CH2:74][C:75]2[C:79]3[CH:80]=[CH:81][CH:82]=[CH:83][C:78]=3[NH:77][CH:76]=2)=[O:72])[CH2:68][OH:69])=[O:66])[CH2:56][C:57]2[CH:58]=[CH:59][C:60]([OH:63])=[CH:61][CH:62]=2)=[O:54])[CH2:48][CH:49]([CH3:51])[CH3:50])=[O:46])[CH2:40][CH:41]([CH3:43])[CH3:42])=[O:38])[CH2:29][CH2:30][CH2:31][NH:32][C:33]([NH2:35])=[NH:34])=[O:27])[CH2:24][CH2:23][CH2:22]1)=[O:20].CC(O)=O>O>[CH3:16][CH2:17][NH:18][C:19]([C@H:21]1[N:25]([C:26]([C@@H:28]([NH:36][C:37]([C@@H:39]([NH:44][C:45]([C@H:47]([NH:52][C:53]([C@@H:55]([NH:64][C:65]([C@@H:67]([NH:70][C:71]([C@@H:73]([NH:84][C:85]([C@@H:87]([NH:94][C:95]([C@H:97]2[NH:102][C:100](=[O:101])[CH2:99][CH2:98]2)=[O:96])[CH2:88][C:89]2[N:93]=[CH:92][NH:91][CH:90]=2)=[O:86])[CH2:74][C:75]2[C:79]3[CH:80]=[CH:81][CH:82]=[CH:83][C:78]=3[NH:77][CH:76]=2)=[O:72])[CH2:68][OH:69])=[O:66])[CH2:56][C:57]2[CH:62]=[CH:61][C:60]([OH:63])=[CH:59][CH:58]=2)=[O:54])[CH2:48][CH:49]([CH3:51])[CH3:50])=[O:46])[CH2:40][CH:41]([CH3:43])[CH3:42])=[O:38])[CH2:29][CH2:30][CH2:31][NH:32][C:33]([NH2:35])=[NH:34])=[O:27])[CH2:24][CH2:23][CH2:22]1)=[O:20]

Komponenten

4

Edukt 2

HCID 178424903HCID 178424903, VerbindungHCID 178476396HCID 178476396, Verbindung

Produkt 1

HCID 178465153HCID 178465153, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Beagle dogs (10-15 Kg) were sedated with medetomidine (80 μg/kg) and an endoscope was inserted via the mouth, oesophagus and stomach into the duodenum. The test solutions (10 ml), comprising leuprolide acetate (Mallinckrodt Inc, St. Louis, Mo.) with or without enhancer reconstituted in deionised water were administered intraduodenally via the endoscope. Following removal of the endoscope, sedation was reversed using atipamezole (400 μg/kg). The parenteral reference solutions comprising 1 mg Leuprolide reconstituted in 0.5 ml sterile water were administered intravenously and subcutaneously respectively.

Aufarbeitung

  1. customremoval of the endoscope, sedation

Quellen und Nachweise

ORD-Eintrag
ord-074707ea44794283a5014b6ce0496f18
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08053429B2

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