1-Phenylpiperazine → 2-(4-Phenylpiperazin-1-yl)acetonitrile

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Reaktionsgleichung

[C:1]1([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:14][C:15]#[N:16]>>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:14][C:15]#[N:16])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

Edukt 2

HCID 70961-Phenylpiperazine

HCID 11534Bromoacetonitrile

Produkt 1

HCID 4372382-(4-Phenylpiperazin-1-yl)acetonitrile

Versuchsvorschrift

The title compound is synthesized by coupling of 1-Phenyl-piperazine and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a white solid; ES-MS: M+=202.2: AtRet=1.95.

Quellen und Nachweise

ORD-Eintrag: ord-6946c533cda84dd7b1df6f88598e6912
Quelldatensatz: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08053457B2

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