Bromoacetonitrile → [4-(2-Ethoxy-ethyl)-piperazin-1-yl]-acetonitrile

HRID 555775

Reaktionsgleichung

[CH2:1]([O:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)[CH3:2].Br[CH2:13][C:14]#[N:15]>>[CH2:1]([O:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][N:9]([CH2:13][C:14]#[N:15])[CH2:10][CH2:11]1)[CH3:2]

Komponenten

Edukt 2

HCID 11534Bromoacetonitrile

HCID 27346431-(2-Ethoxyethyl)piperazine

Produkt 1

HCID 63336683[4-(2-Ethoxy-ethyl)-piperazin-1-yl]-acetonitrile

Versuchsvorschrift

The title compound is synthesized by coupling of 4-(2-Ethoxy-ethyl)-piperazine (commercially available from ABCR GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+H=198.2; 1HNMR(DMSO-d6) 3.70 (s, 2H), 3.45 (q, 2H), 3.40 (q, 2H), 2.40-2.30 (m, 10H), 1.05 (t, 3H).

Aufarbeitung

customanalogously to the preparation of Intermediate 149.2 as a colorless oil

Quellen und Nachweise

ORD-Eintrag: ord-50ac3cb6e71e44babcad2700b39d0b9f
Quelldatensatz: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08053457B2

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