Hydrochloric Acid → Methyl 5-methyl-2-nitrobenzoate

There was dissolved, in 200 mL of N,N-dimethylformamide, 20.0 g of 5-methyl-2-nitrobenzoic acid, 22.9 g of potassium carbonate and then 8.2 mL of methyl iodide were added to the resulting solution and the mixture was stirred at room temperature for 4 hours. To the reaction liquid, there were added 400 mL of water and 200 mL of a 1M hydrochloric acid solution, then extracted with 900 mL of ethyl acetate, the extract was washed with 200 mL of a saturated sodium hydrogen carbonate solution and 200 mL of a saturated common salt solution and the solvent was then distilled off under reduced pressure to thus give 20.6 g of the title compound as a crude product.

1. customTo the reaction liquid, there
2. extractionextracted with 900 mL of ethyl acetate
3. washthe extract was washed with 200 mL of a saturated sodium hydrogen carbonate solution and 200 mL of a saturated common salt solution
4. distillationthe solvent was then distilled off under reduced pressure to thus give 20.6 g of the title compound as a crude product

ORD-Eintrag

ord-f95e301238c74de6887b6a7b0ce6d685

Quelldatensatz

uspto-grants-2011_11

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08058432B2