Water → HCID 17962881, Verbindung

HRID 557579Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 557579
B(Br)(Br)Br.[C:5]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([O:18]C)=[CH:15][CH:16]=2)[C:11]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([CH3:20])[CH2:10][C:9]1([CH3:28])[CH3:27])(=[O:7])[CH3:6].O>ClCCl>[C:5]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=2)[C:11]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([CH3:20])[CH2:10][C:9]1([CH3:28])[CH3:27])(=[O:7])[CH3:6]

Komponenten

5

Edukt 3

HCID 962WaterHCID 25134Boron tribromideHCID 17962883HCID 17962883, Verbindung

Produkt 1

HCID 17962881HCID 17962881, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Boron tribromide (1.30 ml) was added dropwise to a cooled (0° C.) solution of 1-acetyl-6-methoxy-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (0.9 g) in dichloromethane (75 ml). After stirring for 18 h, the reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with water, 5% aq. NaHCO3 and water, dried (MgSO4) and concentrated in vacuo.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water, 5% aq. NaHCO3 and water
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-01ea5e89875a426284cdf93c8a3d7617
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08058441B2

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