Hydrochloric Acid → 1-(3,5-Dibromophenyl)ethanone

HRID 557673

Reaktionsgleichung

Reaktionsgleichung von HRID 557673
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:11])[CH:10]=1)[C:5]([OH:7])=O.C[Li].[CH3:14]COC(C)=O.Cl>CCOCC>[Br:11][C:9]1[CH:8]=[C:4]([C:5](=[O:7])[CH3:14])[CH:3]=[C:2]([Br:1])[CH:10]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 12063Benzoic acid, 3,5-dibromo-HCID 178418348HCID 178418348, Verbindung

Produkt 1

HCID 6218251-(3,5-Dibromophenyl)ethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

To a solution of 3,5-dibromobenzoic acid (2.5 g, 8.9 mmol) in Et2O (30 mL) at 0° C. was added methyllithium (1.6M in Et2O; 12.3 mL, 19.6 mmol) dropwise. The reaction was stirred at 0° C. for 2 hours, and then worked-up with EtOAc and 10% aqueous HCl. The crude material was purified by silica gel chromatography to give the title compound.

Aufarbeitung

  1. customThe crude material was purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-39c48f6d7e864b28b0186d9de9d4f0ef
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08058300B2

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