(S)-6-benzyl-6-aza-spiro[2,5]octan-4-ol → (4S)-6-Azaspiro[2.5]octan-4-ol

HRID 559340Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 559340
C([N:8]1[CH2:15][CH2:14][C:11]2([CH2:13][CH2:12]2)[C@H:10]([OH:16])[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH2:12]1[C:11]2([CH2:14][CH2:15][NH:8][CH2:9][C@H:10]2[OH:16])[CH2:13]1

Komponenten

4

Edukt 1

HCID 25204267(S)-6-benzyl-6-aza-spiro[2,5]octan-4-ol

Produkt 1

HCID 44541813(4S)-6-Azaspiro[2.5]octan-4-ol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

100 mg (S)-6-benzyl-6-aza-spiro[2.5]octan-4-ol were dissolved in 1 ml methanol and hydrogenated over palladium on barium sulfate. After de-benzylation (IPC by GC), the catalyst was filtered and the filtrate was concentrated under reduced pressure to provide the title compound. The hydrochloride salt of the title compound can be obtained by treating the aminoalcohol with HCl in ethyl acetate.

Aufarbeitung

  1. filtrationAfter de-benzylation (IPC by GC), the catalyst was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-bea54a87230f4886bf0b03b93d767af7
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063042B2

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