HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Sodium Carbonate → 1-Benzenesulfonyl-4-(2'-chloro-5'-fluoro-biphenyl-3-yl)-3-isopropyl-imidazolidin-2-one
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Sodium Carbonate | HCID 10340 | — |
| Edukt | 2-Chloro-5-fluorobenzeneboronic acid | HCID 22648116 | — |
| Edukt | 1-Benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one | HCID 67001096 | — |
| Katalysator | HCID 178418807 | HCID 178418807 | — |
| Lösungsmittel | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Produkt | 1-Benzenesulfonyl-4-(2'-chloro-5'-fluoro-biphenyl-3-yl)-3-isopropyl-imidazolidin-2-one | HCID 44548211 | — |
Reaktionsschritte
In analogy to example 1, step 3,1-benzenesulfonyl-4-(3-bromo-phenyl)-3-isopropyl-imidazolidin-2-one (example 12, step 1) was reacted with 2-chloro-5-fluorophenylboronic acid in the presence of dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium dichloromethane adduct and sodium carbonate in dioxane/water to give 1-benzenesulfonyl-4-(2′-chloro-5′-fluoro-biphenyl-3-yl)-3-isopropyl-imidazolidin-2-one as a light yellow oil. MS: 472.9 ([M+H]+)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08063088B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-ed4a196afb274e9eac278dfd0ac6aa61 |
| Quellennotiz | uspto-grants-2011_11 |