Water → 7-Benzothiazolecarboxylic acid

HRID 560314Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 560314
[OH-].[Na+].C[O:4][C:5]([C:7]1[C:15]2[S:14][CH:13]=[N:12][C:11]=2[CH:10]=[CH:9][CH:8]=1)=[O:6].C1COCC1.O>CO>[S:14]1[C:15]2[C:7]([C:5]([OH:6])=[O:4])=[CH:8][CH:9]=[CH:10][C:11]=2[N:12]=[CH:13]1

Komponenten

6

Edukt 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 59316815Methyl benzo[d]thiazole-7-carboxylate

Produkt 1

HCID 450769847-Benzothiazolecarboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

At 0° C. an aq. NaOH solution (50%, 6.0 mL) is added to a solution of benzothiazole-7-carboxylic acid methyl ester in a mixture of MeOH (39 mL), THF (11.7 mL) and water (3.0 mL). The mixture is stirred for 4 h and concentrated in vacuo. At 0° C. water (60 mL) is added and the mixture is made acidic (pH 5) by addition of conc. HCl. After 30 min the precipitate is filtered off, washed with water and dried in vacuo to give the desired product.

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. additionAt 0° C. water (60 mL) is added
  3. additionby addition of conc. HCl
  4. filtrationAfter 30 min the precipitate is filtered off
  5. washwashed with water
  6. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-6fd7288e3c5d487dbfa3fa6a044b37cd
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08063099B2

Notizen zur Reaktion

Wird geladen…