4-(2-Fluoro-4-nitrophenyl)-1lambda~6~,4-thiazinane-1,1-dione → 4-(4-Amino-2-fluorophenyl)thiomorpholine 1,1-dioxide

HRID 56098Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 56098
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:16][CH2:15][S:14](=[O:18])(=[O:17])[CH2:13][CH2:12]1>C1COCC1.[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([N:11]2[CH2:16][CH2:15][S:14](=[O:17])(=[O:18])[CH2:13][CH2:12]2)=[C:2]([F:1])[CH:7]=1

Komponenten

4

Edukt 1

HCID 159843694-(2-Fluoro-4-nitrophenyl)-1lambda~6~,4-thiazinane-1,1-dione

Produkt 1

HCID 435813994-(4-Amino-2-fluorophenyl)thiomorpholine 1,1-dioxide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 4-(2-fluoro-4-nitrophenyl)1,1-dioxidothiomorpholine (4.00 g, 14.58 mmol) in THF (50 mL) was added Pd/C (1.30 g). The reaction mixture was stirred at rt under H2 for 12 h. The mixture was filtered, and the filtrate was concentrated in vacuo to give the title compound as an offwhite solid (2.40 g, 67%).

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-4b4a2f8296c64eaa909b715e8b62270f
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434695B2

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