[F:1][C:2]1([F:11])[CH2:4][CH:3]1[C:5](N(OC)C)=[O:6].Cl[Mg][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[Br-].[Cl-:21].[NH4+]>C1COCC1.C(OCC)C>[Cl:21][C:14]1[CH:19]=[CH:18][C:17]([C:5]([CH:3]2[CH2:4][C:2]2([F:11])[F:1])=[O:6])=[CH:16][CH:15]=1A solution of 2.00 g (12.1 mmol) of the compound from Example 120A in 20 ml of THF was added under argon to 2.87 g (13.3 mmol) of a 1N chlorophenylmagnesium bromide solution in diethyl ether in 20 ml of THF at RT, and the mixture was heated under reflux for 2 h. The reaction mixture was added to saturated aqueous ammonium chloride solution and extracted twice with diethyl ether, and the combined organic phases were dried over magnesium sulfate and concentrated. 2.47 g (94% of theory) of the title compound were obtained and were reacted without further purification.
Wird geladen…
