HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Cyclopropyl-1-(2,4-difluorophenyl)ethanol → 3-[1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Cyclopropyl-1-(2,4-difluorophenyl)ethanol | HCID 24749679 | — |
| Edukt | 3-[1-Cyclopropyl-1-(4-fluorophenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392106 | — |
| Edukt | 3-(2,4-Dichlorophenyl)-3-{5-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-ol | HCID 58392305 | — |
| Produkt | 3-[1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392322 | — |
Reaktionsschritte
The title compound was prepared starting from 500 mg (2.82 mmol) of the compound from Example 8 and 615 mg (3.10 mmol) of the compound from Example 78A in analogy to the synthesis of the compound from Example 95. 227 mg (94% purity, 21% of theory) of the target compound were obtained.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08063234B2 |
| Quelldatensatz | uspto-grants-2011_11 |
| ORD ID | ord-5872915fca674e66b19df19edad8cc3e |
| Quellennotiz | uspto-grants-2011_11 |