Ethyl Acetate → 2-fluoro-N1-(3-morpholinopropyl)benzene-1,4-diamine

HRID 56165Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 56165
[F:1][C:2]1[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:3]=1[NH:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.CCOC(C)=O>[Pd].CO>[F:1][C:2]1[CH:17]=[C:16]([NH2:18])[CH:15]=[CH:14][C:3]=1[NH:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

Komponenten

5

Edukt 2

HCID 8857Ethyl AcetateHCID 29277432-fluoro-N-(3-morpholinopropyl)-4-nitroaniline

Produkt 1

HCID 431684652-fluoro-N1-(3-morpholinopropyl)benzene-1,4-diamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2-fluoro-N-(3-morpholinopropyl)-4-nitroaniline (1.78 g, 6.28 mmol) in mixed solvents of EtOAc (15 mL) and MeOH (15 mL) was added catalyst Pd/C (0.30 g). The reaction was stirred at rt under H2 for 2 h, then filtered. The filtrate was concentrated in vacuo to give the crude product for the next step without further purification.

Aufarbeitung

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-60f431a2f98345b1b92c44836d7122b0
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434695B2

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