Ethyl Bromide → Butanoic acid, 2-ethyl-3-oxo-, methyl ester
Reaktionsgleichung
[C:1]([O:7][CH3:8])(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[CH2:9](Br)[CH3:10].C[O-].[Na+]>CO>[C:3]([CH:2]([CH2:9][CH3:10])[C:1]([O:7][CH3:8])=[O:6])(=[O:4])[CH3:5]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
465 g of methyl acetoacetate and then 458 g of ethyl bromide were added under nitrogen to 720 g of 30% sodium methylate solution in 1200 ml of methanol. The reaction mixture was subsequently boiled at reflux. After distillation of the methanol the residue was poured on to ice-water. It was then extracted with n-hexane and water. The organic phases were combined and dried. After evaporation of the solvent and distillation there were obtained 328 g (56.9%) of methyl 2-acetylbutyrate, b.p. 77°-79°/15 Torr.
Aufarbeitung
- temperatureat reflux
- distillationAfter distillation of the methanol the residue
- additionwas poured on to ice-water
- extractionIt was then extracted with n-hexane and water
- customdried
- customAfter evaporation of the solvent
- distillationdistillation there
Quellen und Nachweise
- ORD-Eintrag
- ord-f9b363bf630049efa482b18098a1d4e7
- Quelldatensatz
- uspto-grants-1993_09
- Patentnummer
- US05245056
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