Sodium Hydroxide → 1-(6-Chloropyrimidin-4-yl)azetidin-3-ol

HRID 562453Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 562453
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[OH-].[Na+].[OH:11][CH:12]1[CH2:15][NH:14][CH2:13]1>O>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:14]2[CH2:15][CH:12]([OH:11])[CH2:13]2)[CH:7]=1

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 709434,6-DichloropyrimidineHCID 15142903-Hydroxyazetidine

Produkt 1

HCID 579250791-(6-Chloropyrimidin-4-yl)azetidin-3-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

7.3 g (48.7 mmol) of 4,6-dichloropyrimidine are suspended in 140 ml of water, and 47 ml 1 N aqueous sodium hydroxide solution are added. 5.3 g (48.7 mmol) of 3-hydroxyazetidine are added, and the reaction mixture is stirred at 90° C. for 3 d. After cooling to RT, the reaction mixture is concentrated under reduced pressure and reacted further without further purification.

Aufarbeitung

  1. temperatureAfter cooling to RT
  2. concentrationthe reaction mixture is concentrated under reduced pressure
  3. customreacted further without further purification

Quellen und Nachweise

ORD-Eintrag
ord-9ac6158955864f2aa78d7c64f0ec1ce0
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08067407B2

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