Sulfur dichloride → 3-(3-Fluorophenyl)propanoyl chloride

HRID 56247

Reaktionsgleichung

[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][CH:7]=1.[Cl:13]SCl>>[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([Cl:13])=[O:12])[CH:5]=[CH:6][CH:7]=1

Komponenten

Edukt 2

HCID 25353Sulfur dichloride

HCID 27374893-(3-Fluorophenyl)propionic acid

Produkt 1

HCID 189935013-(3-Fluorophenyl)propanoyl chloride

Versuchsvorschrift

A mixture of 3-(3-fluorophenyl)propanoic acid (2.50 g, 14.9 mmol) and dichlorosulfane (10 mL) under N2 was refluxed for 3 h. The mixture was cooled to rt and concentrated in vacuo to give the title compound, which was used for next step without further purification.

Aufarbeitung

temperaturewas refluxed for 3 h
concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag: ord-119617a6c7804e7aa0f70ecb08b9ebb9
Quelldatensatz: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09434695B2

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