Ethanol → 4-(3-Fluorophenoxy)butanoic acid

HRID 56251

Reaktionsgleichung

Reaktionsgleichung von HRID 56251
[OH-].[K+].O.C(O)C.[F:7][C:8]1[CH:9]=[C:10]([CH:20]=[CH:21][CH:22]=1)[O:11][CH2:12][CH2:13][CH2:14][C:15]([O:17]CC)=[O:16]>C(Cl)Cl>[F:7][C:8]1[CH:9]=[C:10]([CH:20]=[CH:21][CH:22]=1)[O:11][CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16]

Komponenten

6

Edukt 4

HCID 702EthanolHCID 962WaterHCID 14797Potassium HydroxideHCID 21812847Ethyl 4-(3-fluoro-phenoxy)butanoate

Produkt 1

HCID 64860154-(3-Fluorophenoxy)butanoic acidAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

To a solution of KOH (0.24 g, 4.28 mmol) in mixed solvents of water (3 mL) and ethanol (3 mL) under N2 was added ethyl 4-(3-fluorophenoxy)butanoate (0.30 g, 1.33 mmol) in one portion and the mixture was stirred at 40° C. for 4 h. It was then cooled to rt and 20 mL of DCM was added. The organic layer was washed with brine (20 mL×2), dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a white solid (0.25 g, 96%).

Aufarbeitung

  1. temperatureIt was then cooled to rt
  2. washThe organic layer was washed with brine (20 mL×2)
  3. dry with materialdried over anhydrous Na2SO4
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fdaf1e14d6bf43bcbc8ae6ddeb79e2ae
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434695B2

Verknüpfte Notizen

Wird geladen…