Sulfur dichloride → 4-(3-Fluorophenoxy)butanoyl chloride
Reaktionsgleichung
[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[O:5][CH2:6][CH2:7][CH2:8][C:9](O)=[O:10].[Cl:15]SCl>>[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[O:5][CH2:6][CH2:7][CH2:8][C:9]([Cl:15])=[O:10]Komponenten
3
Versuchsvorschrift
A solution of 4-(3-fluorophenoxy)butanoic acid (3.00 g, 15.1 mmol) in dichlorosulfane (15 mL) under N2 was refluxed for 3 h. The mixture was cooled to rt and concentrated in vacuo to give the title compound, which was used for next step without further purification.
Aufarbeitung
- concentrationconcentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-f4e72ac7cd384758b6534f103e26e766
- Quelldatensatz
- uspto-grants-2016_09
- Patentnummer
- US09434695B2
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