Sulfur dichloride → 4-(3-Fluorophenoxy)butanoyl chloride

HRID 56252

Reaktionsgleichung

[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[O:5][CH2:6][CH2:7][CH2:8][C:9](O)=[O:10].[Cl:15]SCl>>[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[O:5][CH2:6][CH2:7][CH2:8][C:9]([Cl:15])=[O:10]

Komponenten

Edukt 2

HCID 25353Sulfur dichloride

HCID 64860154-(3-Fluorophenoxy)butanoic acid

Produkt 1

HCID 900231674-(3-Fluorophenoxy)butanoyl chloride

Versuchsvorschrift

A solution of 4-(3-fluorophenoxy)butanoic acid (3.00 g, 15.1 mmol) in dichlorosulfane (15 mL) under N2 was refluxed for 3 h. The mixture was cooled to rt and concentrated in vacuo to give the title compound, which was used for next step without further purification.

Aufarbeitung

concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag: ord-f4e72ac7cd384758b6534f103e26e766
Quelldatensatz: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09434695B2

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