Isopropanol → Imatinib Mesylate

HRID 562558

Reaktionsgleichung

Reaktionsgleichung von HRID 562558
C(O)(C)C.[CH3:5][C:6]1[CH:7]=[CH:8][C:9]([NH:25][C:26]([C:28]2[CH:29]=[CH:30][C:31]([CH2:34][N:35]3[CH2:40][CH2:39][N:38]([CH3:41])[CH2:37][CH2:36]3)=[CH:32][CH:33]=2)=[O:27])=[CH:10][C:11]=1[NH:12][C:13]1[N:14]=[CH:15][CH:16]=[C:17]([C:19]2[CH:20]=[CH:21][CH:22]=[N:23][CH:24]=2)[N:18]=1.[CH3:42][S:43]([OH:46])(=[O:45])=[O:44]>O>[CH3:5][C:6]1[CH:7]=[CH:8][C:9]([NH:25][C:26]([C:28]2[CH:33]=[CH:32][C:31]([CH2:34][N:35]3[CH2:36][CH2:37][N:38]([CH3:41])[CH2:39][CH2:40]3)=[CH:30][CH:29]=2)=[O:27])=[CH:10][C:11]=1[NH:12][C:13]1[N:14]=[CH:15][CH:16]=[C:17]([C:19]2[CH:20]=[CH:21][CH:22]=[N:23][CH:24]=2)[N:18]=1.[CH3:42][S:43]([OH:46])(=[O:45])=[O:44]

Komponenten

5

Edukt 3

HCID 3776Isopropanol2×HCID 5291ImatinibHCID 6395Methanesulfonic Acid

Produkt 1

HCID 123596Imatinib Mesylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

The solution of imatinib mesylate and isopropanol is prepared by a process comprising: providing a suspension of imatinib base and isopropanol containing up to 7% by weight of water; admixing the suspension with cooled methanesulfonic acid; and maintaining the mixture at the cooled temperature to obtain a solution of imatinib mesylate. Preferably, the suspension of imatinib base is prepared by suspending imatinib base in isopropanol containing up to 7% by weight of water at a temperature of about −10° C. to about −5° C., more preferably, at a temperature of about −10° C. Preferably, the isopropanol contains up to 5% of water by weight. Preferably, methanesulfonic acid is added to the suspension at a temperature of about 0° C. to about −10° C., more preferably at a temperature of about −10° C., most preferably in a stoichiometric amount. Preferably, the solution is maintained at a temperature of about 0° C. to about −20° C., more preferably, at a temperature of about −15° C. Preferably, the solution is maintained for a period of about 10 hours to about 24 hours, more preferably for about 12 hours to about 16 hours, most preferably about 12 hours.

Aufarbeitung

  1. customproviding
  2. temperatureand maintaining the mixture at the cooled temperature

Quellen und Nachweise

ORD-Eintrag
ord-1ff0e65533fe4bca87e11e04a16be38f
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08067421B2

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