Nitrogen → 2-(3-Fluorophenoxy)-2-methylpropanoyl chloride

Reaktionsgleichung

[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[O:5][C:6]([CH3:11])([CH3:10])[C:7](O)=[O:8].[Cl:15]SCl.N#N>>[F:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[O:5][C:6]([CH3:11])([CH3:10])[C:7]([Cl:15])=[O:8]

Komponenten

Edukt 3

HCID 947Nitrogen

HCID 25353Sulfur dichloride

HCID 222707202-(3-fluorophenoxy)-2-methylPropanoic acid

Produkt 1

HCID 821138502-(3-Fluorophenoxy)-2-methylpropanoyl chloride

Versuchsvorschrift

To 2-(3-fluorophenoxy)-2-methylpropanoic acid (1.70 g, 8.58 mmol) was added dichlorosulfane (15 mL) dropwise under N2 and the mixture was refluxed for 3 h. The mixture was cooled to rt and concentrated in vacuo to give the title compound as yellow oil, which was used for next step without further purification.