Hydrogen Bromide → 3-Bromo-4-hydroxyphenylacetic acid

HRID 563530

Reaktionsgleichung

Reaktionsgleichung von HRID 563530
[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[O:8]C.Br>C(O)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[OH:8]

Komponenten

4

Edukt 2

HCID 260Hydrogen BromideHCID 1366153-Bromo-4-methoxyphenylacetic acid

Produkt 1

HCID 27696283-Bromo-4-hydroxyphenylacetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

3-Bromo-4-methoxyphenylacetic acid (1.3 g, 5.6 mmol) was heated in a solution of hydrogen bromide (3 mL) and acetic acid (3 mL) at 100° C. overnight. The mixture was then partitioned between EtOAc and H2O, and the aqueous layer was separated and extracted with EtOAc. The combined organic layers were washed with brine, dried over MgSO4, filtered, and concentrated to give the title compound.

Aufarbeitung

  1. customThe mixture was then partitioned between EtOAc and H2O
  2. customthe aqueous layer was separated
  3. extractionextracted with EtOAc
  4. washThe combined organic layers were washed with brine
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-aa313f2ce17b461c8e45403b4c2cb189
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08067445B2

Verknüpfte Notizen

Wird geladen…