Hydrochloric Acid → Clofibric Acid

HRID 563628

Reaktionsgleichung

Reaktionsgleichung von HRID 563628
C([O:3][C:4](=[O:16])[C:5]([O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1)([CH3:7])[CH3:6])C.[Li+].[OH-].Cl>C1COCC1>[Cl:15][C:12]1[CH:11]=[CH:10][C:9]([O:8][C:5]([CH3:7])([CH3:6])[C:4]([OH:16])=[O:3])=[CH:14][CH:13]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 2796ClofibrateHCID 3939Lithium Hydroxide

Produkt 1

HCID 2797Clofibric Acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 2-(4-chlorophenoxy)isobutyric acid ethyl ester (1.0 g, 4.12 mmol) in THF (10 mL) was treated with 1N aqueous LiOH (10 mL) and stirred overnight at room temperature. The mixture was acidified with 1N aqueous HCl to pH 3-4 and extracted three times with EtOAc. The combined organic layers were dried and concentrated to give the title compound.

Aufarbeitung

  1. extractionextracted three times with EtOAc
  2. customThe combined organic layers were dried
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-534f193b409a4a5697970c15e0961994
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08067445B2

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