1-Methyl-4-piperidone → HCID 1476965, Verbindung

HRID 563862Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 563862
[CH3:1][N:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1.CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>C1(C)C=CC=CC=1>[CH3:11][N:12]([CH:14]=[C:4]1[C:5](=[O:8])[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3]1)[CH3:13]

Komponenten

4

Edukt 2

HCID 740491-Methyl-4-piperidoneHCID 78373Dimethylformamide dimethyl acetal

Produkt 1

HCID 1476965HCID 1476965, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of 1-methylpiperidin-4-one (10 g, 88 mmol) in toluene (100 mL) was added 1,1-dimethoxy-N,N-dimethylmethanamine (52.7 g, 0.442 mol). The solution was heated to reflux overnight. The solvents were evaporated in vacuo, heptane (100 ml) was added and the solvents evaporated again to give the desired product. NMR indicated that the product was 70-80% pure and it was used in the next step without further purification.

Aufarbeitung

  1. temperatureThe solution was heated
  2. temperatureto reflux overnight
  3. customThe solvents were evaporated in vacuo, heptane (100 ml)
  4. additionwas added
  5. customthe solvents evaporated again

Quellen und Nachweise

ORD-Eintrag
ord-25d2b5b044744d21b224d9b5faf8bfe5
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08067589B2

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