Water → 1-Methyl-1H-indazol-5-ol

HRID 563893

Reaktionsgleichung

Reaktionsgleichung von HRID 563893
N[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[N:6]=[CH:5]2.[OH2:12].[OH-].[Na+]>P(=O)(O)(O)O>[OH:12][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:11])[N:6]=[CH:5]2

Komponenten

5

Edukt 3

HCID 962Water2×HCID 14798Sodium HydroxideHCID 27680321-methyl-1H-indazol-5-amine

Produkt 1

HCID 441192401-Methyl-1H-indazol-5-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1004Phosphoric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
180 °C

Versuchsvorschrift

5-Amino-1-methylindazole (1.56 g) in phosphoric acid (13 ml) containing water (3 ml) was heated to 180° C. for 18 hours, cooled to ambient temperature, poured into water (5 ml) then neutralised with aqueous sodium hydroxide. The solid that precipitated was filtered from solution, washed with cold water then sucked to dryness to give was hydrolysed to give 5-hydroxyl-1-methylindazole as a brown solid, (1.18 g).

Aufarbeitung

  1. temperaturecooled to ambient temperature
  2. customThe solid that precipitated
  3. filtrationwas filtered from solution
  4. washwashed with cold water
  5. customto give

Quellen und Nachweise

ORD-Eintrag
ord-00365a0cbbd14c7a905837875a647ed6
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08067592B2

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