2,6-Difluoro-3-nitrobenzoic acid → 3-Amino-2,6-difluorobenzoic acid

HRID 564290

Reaktionsgleichung

Reaktionsgleichung von HRID 564290
[F:1][C:2]1[C:10]([N+:11]([O-])=O)=[CH:9][CH:8]=[C:7]([F:14])[C:3]=1[C:4]([OH:6])=[O:5].[H][H]>[C].[Pd].CO>[NH2:11][C:10]1[C:2]([F:1])=[C:3]([C:7]([F:14])=[CH:8][CH:9]=1)[C:4]([OH:6])=[O:5]

Komponenten

5

Edukt 2

HCID 3026292,6-Difluoro-3-nitrobenzoic acidHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 184053523-Amino-2,6-difluorobenzoic acidAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 2,6-difluoro-3-nitrobenzoic acid and 10% palladium carbon added to 10 ml of methanol was stirred in a hydrogen atmosphere at room temperature for 2 hours. The catalyst was filtered off and then the solvent was removed under a reduced pressure to obtain the desired product (Yield: 93%) as a white solid.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was removed under a reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3341bca4d0554b49aae95f7eac297a40
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08067638B2

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