Acetone → Diallyl sulfone

HRID 564339Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 564339
[CH2:1](O)[CH:2]=[CH2:3].O[O:6][S:7]([O-:9])=O.[K+].[CH3:11][C:12]([CH3:14])=O>O>[CH2:1]([S:7]([CH2:14][CH:12]=[CH2:11])(=[O:9])=[O:6])[CH:2]=[CH2:3]

Komponenten

5

Edukt 3

HCID 180AcetoneHCID 7858Allyl AlcoholHCID 23707502Potassium hydroxy sulfite

Produkt 1

HCID 159797Diallyl sulfoneAusbeute 72 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A solution of allyl alcohol isomer A from Step 2 (7.11 g, 16.65 mmol) and oxone (30.75 g, 50.0 mmol) in acetone (100 mL) and water (25 mL) was stirred at RT overnight then filtered, diluted with water and AcOEt, extracted with AcOEt, dried and concentrated. The residue is purified was purified by flash-chromatography over silica gel (eluted with Hexanes/AcOEt 99:1 to 60:40) to provide 5.50 g (72%) of allylsulfone.

Aufarbeitung

  1. filtrationthen filtered
  2. additiondiluted with water and AcOEt
  3. extractionextracted with AcOEt
  4. customdried
  5. concentrationconcentrated
  6. customThe residue is purified
  7. customwas purified by flash-chromatography over silica gel (eluted with Hexanes/AcOEt 99:1 to 60:40)

Quellen und Nachweise

ORD-Eintrag
ord-d6e63dc26e2248b4b93a5bb95fa6cb07
Quelldatensatz
uspto-grants-2011_11
Patentnummer
US08067621B2

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